Dicalcium Glycyrrhizate is a highly effective, licorice-derived soothing agent designed to suppress inflammatory responses and calm reactive skin. This salt form provides targeted relief for redness while reinforcing the skin’s natural resilience against environmental stressors.
- INCI Name:
- Dicalcium Glycyrrhizate
- Chemical/Scientific Name:
- Calcium glycyrrhizinate; Calcium salt of glycyrrhizic acid
- Common Aliases:
- Licorice root salt, Calcium glycyrrhizate
| Category: | Active Substances |
| Source Origin: | Plant-derived (Glycyrrhiza glabra) |
| Comedogenic Rating: | 0 |
| Primary Industries: | Dermatological Skincare, Oral Care, Quasi-drugs |
| Solubility: | Water-soluble |
At a Glance: Properties & Effects
| Soothing/Calming: | |
| Redness Reduction: | |
| Barrier Repair: | |
| Irritation Risk: |
- Primary Benefits: Rapidly reduces skin sensitivity, alleviates post-procedural redness, inhibits the degradation of internal Sodium Hyaluronate, and supports a more even skin tone.
- Potential Risks: Generally considered non-irritating; no significant risks identified at standard cosmetic concentrations.
Biological Action & Cosmetic Profile
Naturally occurring in the roots of the licorice plant (Glycyrrhiza glabra), the glycyrrhizate molecule undergoes a specific neutralization process with calcium to form this stable salt. The resulting compound functions as a powerful anti-inflammatory by suppressing pro-inflammatory cytokines such as TNF-α and IL-1. Unlike its cousin, Dipotassium Glycyrrhizate, the dicalcium version introduces calcium ions to the skin surface, which are essential for the terminal differentiation of keratinocytes and the maintenance of a robust acid mantle.The compound further exerts a protective effect on the skin’s extracellular matrix by inhibiting hyaluronidase. This enzyme is responsible for the breakdown of moisture-binding polysaccharides, meaning topically applied glycyrrhizates help preserve the skin’s natural hydration levels. Clinical observations have noted its ability to act as a “steroid-sparing” agent, providing calming effects comparable to mild corticosteroids without the associated risks of skin thinning or rebound sensitivity.Formulators frequently utilize this ingredient in “quasi-drug” products—a regulatory category in Japan and Korea—to treat skin roughness and persistent irritation. Its ability to disrupt the arachidonic acid cascade prevents the biochemical triggers that lead to itching and swelling. Consequently, the ingredient is a staple in formulations for eczema, rosacea, and adult acne where inflammation is a primary concern.
Broader Applications & Origins
In the pharmaceutical sector, this ingredient is often found in oral care products to treat gingivitis and in ophthalmic solutions to soothe ocular inflammation. The licorice root itself has been used for centuries in traditional medicine, but the isolation of the dicalcium salt allows for high purity and consistent therapeutic performance. Because it is water-soluble and stable across a broad pH range, it integrates seamlessly into various product formats, including aqueous serums, light emulsions, and heavy ointments.
Routine Integration
- Synergies: Works exceptionally well when combined with Allantoin or Panthenol for enhanced barrier repair. It also complements Niacinamide in addressing blotchiness and uneven texture.
- Conflicts: No known significant cosmetic ingredient conflicts. It is generally compatible with both acidic actives and neutral soothing agents.
Clinical Consensus & Safety
The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated glycyrrhizic acid and its salts, concluding that they are safe as used in current cosmetic practices. Research data confirms that these compounds are non-sensitizing and do not exhibit phototoxic potential even at concentrations significantly higher than those typically found in over-the-counter skincare. Regulatory bodies in the EU (CosIng) and Asia classify it as a safe skin-conditioning and soothing agent.
Does Dicalcium Glycyrrhizate help with acne?
While not an antimicrobial agent like benzoyl peroxide, it helps manage acne by reducing the underlying inflammation and redness associated with breakouts. This makes it an excellent supportive ingredient for calming the irritation often caused by harsher acne treatments.
How does it differ from licorice extract?
Licorice extract is a complex mixture of many compounds, including glabridin and licochalcone. Dicalcium Glycyrrhizate is a purified salt of one specific active component (glycyrrhizic acid), allowing for more predictable anti-inflammatory performance and better formula stability compared to crude extracts.
Is it safe for sensitive skin?
Yes, this ingredient is specifically indicated for sensitive and reactive skin types. It is frequently used in dermatological formulas to minimize the stinging and discomfort associated with a compromised skin barrier.