Potassium Myristoyl Hydrolyzed Collagen is a high-performance lipoamino acid surfactant that delivers exceptionally mild cleansing while simultaneously conditioning the skin. By chemically bonding a fatty acid to protein fragments, this ingredient maintains the skin barrier’s integrity far more effectively than traditional harsh sulfates.
- INCI Name:
- Potassium Myristoyl Hydrolyzed Collagen
- Chemical/Scientific Name:
- L-Collagen, hydrolyzed, reaction products with tetradecanoyl chloride, potassium salts
- Common Aliases:
- Potassium Myristoyl Collagen, Acylated Collagen, Collagen-Myristic Acid Condensate
| Category: | Surface-Active Substances |
| Source Origin: | Bovine, Porcine, or Marine-derived protein combined with synthetic or vegetable fatty acids |
| Comedogenic Rating: | 0-1 |
| Primary Industries: | Dermatological skincare, professional haircare, luxury cosmetics |
| Solubility: | Water-soluble |
At a Glance: Properties & Effects:
| Soothing/Calming | |
| Hydration/Moisture | |
| Texture Enhancement | |
| Irritation Risk |
Primary Benefits:
- Provides a creamy, rich foam without stripping essential epidermal lipids.
- Leaves a silky, non-occlusive film that improves skin softness and elasticity.
- Reduces the irritation potential of other anionic surfactants in a formulation.
- Acts as a humectant due to the peptide chains within the Hydrolyzed Collagen structure.
Potential Risks:
- Sourced from animal proteins, making it unsuitable for vegan-certified products.
- Risk of irritation is negligible, though sensitive individuals should always patch test.
Biological Action & Cosmetic Profile:
As a condensation product, this molecule represents a hybrid between the hydrophobic properties of Myristic Acid and the hydrophilic nature of Collagen peptides. The acylation process attaches the fatty acid chain to the amino groups of the protein, creating a surfactant with a large, bulky head group. This structural configuration prevents the molecule from penetrating the stratum corneum deeply, which significantly lowers the risk of cytokine release and inflammation compared to smaller surfactants like Sodium Lauryl Sulfate.Cleansing mechanisms rely on the ability of the myristoyl tail to sequester sebum and debris, while the protein backbone anchors to the skin surface to provide conditioning. Clinical studies involving protein-based surfactants demonstrate that they exert a protective effect on the skin’s moisture barrier by forming a “buffer” during the wash process. Unlike soap-based cleansers, these lipoamino acids maintain a more skin-neutral pH environment, preventing the swelling and subsequent drying of the keratinocytes.Surface properties of this ingredient also enhance the sensory profile of a product. Formulations containing this salt exhibit a distinct “cushion” during application, reducing friction between the hands and the face. After rinsing, the residual Hydrolyzed Collagen fragments continue to attract moisture to the upper layers of the epidermis, mitigating the “tight” feeling often associated with facial cleansing.
Broader Applications & Origins:
Manufacture of this ingredient involves a Schotten-Baumann reaction, where the acid chloride of Myristic Acid reacts with collagen peptides in an alkaline medium. Historically, these protein-fatty acid condensates were developed for the medical field to treat damaged skin before transitioning into premium dermatological cleansers. Beyond facial care, the ingredient is highly valued in shampoos for chemically treated hair, as the protein fragments help to smooth the cuticle and improve manageability without heavy silicone buildup.
Routine Integration:
Synergies:
- Glycerin and Sodium PCA: Enhance the humectant properties for extreme dry skin.
- Cocamidopropyl Betaine: Works to further stabilize the foam and increase viscosity.
- Mild anionic surfactants: Use in conjunction to create high-performance, low-irritation cleansing systems.
Clinical Consensus & Safety:
The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated acylated amino acids and their salts, concluding they are safe for use in cosmetic formulations. Because the hydrolyzed protein fragments are too large to traverse the skin barrier, systemic toxicity is not a concern. Toxicological data indicates that Potassium Myristoyl Hydrolyzed Collagen is neither a sensitizer nor a significant primary irritant, even in concentrated rinse-off applications. The European Commission’s CosIng database lists its functions as cleansing, hair conditioning, and skin protecting, confirming its multi-functional safety profile for global distribution.
Is Potassium Myristoyl Hydrolyzed Collagen vegan?
Typically, this ingredient is not vegan. The “collagen” component is almost always derived from animal sources such as fish, cattle, or pigs. Consumers seeking vegan alternatives should look for “Potassium Myristoyl Hydrolyzed Wheat Protein” or synthetic biomimetic peptides.
Does this ingredient help with wrinkles?
While Collagen is associated with anti-aging, this specific surfactant form is primarily used for cleansing and surface conditioning. It does not penetrate deep enough to stimulate new collagen production in the dermis, but it can make wrinkles appear less prominent by temporary hydration of the skin surface.
Is it safe for eczema-prone skin?
Yes, this is one of the most recommended surfactants for compromised skin barriers. Its large molecular size and protein-rich composition prevent it from disrupting the lipid bilayer, making it far safer for eczema or rosacea sufferers than standard soaps.

