Sh-Polypeptide-3, also known as Keratinocyte Growth Factor (KGF), is a potent recombinant peptide that specifically stimulates the proliferation and migration of epidermal cells. It serves as a high-precision signaling molecule to accelerate barrier repair and visible skin rejuvenation.
- INCI Name:
- Sh-Polypeptide-3
- Chemical/Scientific Name:
- Recombinant human Fibroblast Growth Factor-7 (FGF-7)
- Common Aliases:
- KGF, rh-Oligopeptide-5, Keratinocyte Growth Factor
| Category: | Active Substances |
| Source Origin: | Biotechnological (Recombinant DNA technology) |
| Comedogenic Rating: | 0 |
| Primary Industries: | Dermatology, Post-Procedure Care, Hair Loss Treatment |
| Solubility: | Water-soluble |
At a Glance: Properties & Effects
| Anti-Aging/Renewal: | |
| Barrier Repair: | |
| Soothing/Calming: | |
| Irritation Risk: |
Primary Benefits:
- Accelerates the natural wound healing process by stimulating keratinocyte movement.
- Increases epidermal thickness to combat age-related skin thinning.
- Supports follicle health for improved hair density and length.
- Strengthens the skin barrier against environmental stressors.
Potential Risks:
- Requires refrigeration or stabilized delivery systems to maintain biological activity.
- Higher formulation cost compared to traditional synthetic peptides.
Biological Action & Cosmetic Profile
Recombinant human peptides function as specialized ligands for specific cellular receptors. Sh-Polypeptide-3 acts as an analog to endogenous Keratinocyte Growth Factor (KGF), primarily targeting the Fibroblast Growth Factor Receptor 2b (FGFR2b). This receptor is found almost exclusively in epithelial cells, meaning the peptide provides highly targeted action without affecting the underlying dermal fibroblasts directly. Once bound, it initiates the Ras-MAPK signaling pathway, which tells the cell to divide and migrate toward areas of damage.Epidermal integrity depends on the rapid turnover of keratinocytes. In aging skin, this process slows significantly, leading to a dull complexion and a fragile barrier. This growth factor facilitates the transition of cells from the basal layer to the stratum corneum, effectively “thickening” the living layers of the epidermis. Because it does not directly stimulate Collagen producing fibroblasts, it is often paired with other growth factors to provide a comprehensive anti-aging effect across all skin layers.
Broader Applications & Origins
Laboratory production of this peptide involves inserting the human DNA sequence for KGF into a host microorganism, typically E. coli, via fermentation. This process ensures the resulting molecule is bio-identical to the proteins found in human skin. Beyond facial rejuvenation, research indicates significant efficacy in scalp health. In hair follicles, the peptide protects the epithelial sheath from environmental damage and can prolong the anagen (growth) phase of the hair cycle.Medical-grade applications often utilize Sh-Polypeptide-3 for post-laser recovery. By speeding up re-epithelialization, the peptide reduces downtime after aggressive chemical peels or microneedling. It works harmoniously with soothing agents like Allantoin and Centella Asiatica Extract to calm the skin while actively repairing physical micro-trauma.
Routine Integration
Synergies:
- Barrier Lipids: Combining the peptide with Ceramide Np provides both signaling and structural support for the barrier.
- Humectants: Use alongside Sodium Hyaluronate or Glycerin to maintain the hydration levels necessary for cell migration.
- Antioxidants: Formulations featuring Niacinamide help stabilize the skin environment, allowing growth factors to function optimally.
- Soothing Agents: High concentrations of Panthenol assist in the enzymatic processes triggered by Sh-Polypeptide-3.
Conflicts:No significant chemical conflicts exist for this peptide. However, avoid using it simultaneously with high-strength exfoliating acids (like Glycolic Acid) as low pH environments may denature the protein structure.
Clinical Consensus & Safety
Dermatological safety assessments by the Cosmetic Ingredient Review (CIR) and general scientific consensus categorize recombinant human growth factors as safe for topical cosmetic use. Because these proteins are large molecules, they typically do not penetrate systemic circulation but remain active within the upper layers of the skin. Peer-reviewed studies in journals like The FASEB Journal and Journal of Investigative Dermatology confirm that KGF significantly promotes epithelial cell growth without the irritation risks associated with retinoids.
Is Sh-Polypeptide-3 effective for hair loss?
Clinical data suggests that Keratinocyte Growth Factor is highly beneficial for hair density. It works by stimulating the proliferation of cells in the hair follicle and protecting the follicle from oxidative stress and UV radiation.
How does this differ from EGF?
While Epidermal Growth Factor (EGF) targets a broad range of cells, Sh-Polypeptide-3 (KGF) is much more specific. It primarily affects epithelial cells, making it a more targeted option for barrier repair and hair health without broader metabolic effects on other cell types.
Can I use this after a chemical peel?
Yes, this ingredient is often recommended for post-procedure care. Its ability to trigger rapid cell migration helps the skin reform a protective barrier more quickly, reducing the risk of infection and shortening the recovery window.