Ceramide NG is a skin-identical sphingolipid that reinforces the stratum corneum barrier to significantly reduce trans-epidermal water loss (TEWL). By replenishing the intercellular lipid matrix, it helps maintain skin structural integrity and protects against environmental aggressors.
- INCI Name:
- Ceramide NG
- Chemical/Scientific Name:
- N-stearoyl sphinganine
- Common Aliases:
- Ceramide 2
| Category: | Moisturizers |
| Source Origin: | Synthetic or Yeast-derived (Bio-fermentation) |
| Comedogenic Rating: | 0 |
| Primary Industries: | Skincare, Haircare, Personal Care |
| Solubility: | Oil-soluble |
At a Glance: Properties & Effects
| Barrier Repair: | |
| Hydration/Moisture: | |
| Soothing/Calming: | |
| Irritation Risk: |
Primary Benefits:
- Deeply restores the skin’s natural moisture barrier.
- Enhances skin elasticity and smoothness.
- Prevents dryness and dehydration by locking in moisture.
- Protects the epidermis from external irritants and pollutants.
Potential Risks:
- Extremely low risk of irritation; generally considered safe for all skin types.
- May feel heavy in high concentrations if not formulated with proper emollients.
Biological Action & Cosmetic Profile
As a critical component of the human stratum corneum, Ceramide NG functions within the “brick and mortar” model of the skin. The corneocytes act as bricks, while the lipid matrix—composed of ceramides, Cholesterol, and free fatty acids—serves as the mortar. This specific ceramide features a sphinganine backbone linked to a Stearic Acid chain. Its presence is essential for maintaining the lamellar structure of the lipid bilayer, which regulates the passage of water and solutes.
The molecular structure of this sphingolipid allows it to integrate seamlessly into the skin’s existing lipid pathways. When applied topically, it compensates for the natural decline in ceramide production caused by aging, harsh surfactants, or environmental stress. By filling the gaps between skin cells, it creates a semi-permeable seal that prevents moisture from evaporating while maintaining the flexibility of the skin surface.
Beyond simple occlusion, Ceramide NG facilitates long-term barrier recovery. Research suggests that while occlusives provide immediate relief, skin-identical lipids like this one signal the skin to repair its own physiological barrier. This makes it particularly valuable for treating conditions characterized by barrier dysfunction, such as atopic dermatitis or xerosis.
Broader Applications & Origins
In the hair care industry, Ceramide NG is utilized to repair the hair cuticle. Similar to its role in the skin, it acts as a cement that holds the hair scales together, resulting in improved tensile strength, shine, and resistance to chemical processing. Most modern versions of this ingredient are produced via bio-fermentation of yeast, ensuring high purity and a sustainable alternative to animal-derived lipids.
Routine Integration
Synergies:
- Barrier Triad: Combines optimally with Cholesterol and fatty acids like Behenic Acid or Palmitic Acid to mimic the natural skin ratio.
- Humectants: Works effectively alongside Glycerin or Sodium Hyaluronate to both attract and retain moisture.
- Other Ceramides: Often blended with Ceramide Np, Ceramide Ap, and Ceramide Eop for a comprehensive multi-ceramide complex.
Conflicts:
- No known biochemical conflicts; safe for use with retinoids, acids, and vitamin C.
Clinical Consensus & Safety
The Cosmetic Ingredient Review (CIR) Expert Panel has evaluated Ceramides, including Ceramide NG, and concluded they are safe for use in cosmetic formulations. Clinical studies published in journals such as the Journal of Investigative Dermatology demonstrate that topical application of skin-identical lipids significantly improves skin hydration levels and reduces clinical signs of dryness. No significant evidence of sensitization or irritation has been reported even in concentrations exceeding standard formulation levels.
Is Ceramide NG the same as Ceramide 2?
Yes. Ceramide NG is the updated INCI name for Ceramide 2. The “NG” stands for non-glycosylated, identifying the specific sphingoid base structure used in the molecule.
Will Ceramide NG cause breakouts on oily skin?
No. This ingredient is non-comedogenic and has a rating of 0 on the comedogenicity scale. It is naturally present in all skin types and is necessary for barrier health, even in acne-prone individuals.
Can I use this ingredient with Retinol?
Yes. Integrating this lipid into a routine containing Retinol is highly recommended, as it helps mitigate the dryness and irritation often associated with retinoid use.